In the univariate analysis, male gender, age (≥48 years), Alb (<4.0 g/dL), PLT (<15 × 104/μL), AFP (≥5.5 ng/mL) and FIB-4 index (≥2.5) were significantly associated with HCC occurrence (Table 2). The gene discussed is ALB; the disease is hepatocellular carcinoma.