The study performed by Komdeur et al. determining CD103+ as a possible predictive biomarker for cervical cancer, made a distinction between intraepithelial and stromal tumor-infiltrating CD8+ lymphocytes, pointing out that CD8+ CTLs expressing CD103+ were more prominent in the epithelial region and might have a higher effect on prognosis [50]. This evidence concerns the gene ITGAE and cervical cancer.