Elevated levels of these kinds of compounds together with high free-iron content may accelerate OS-induced cardiac damage via the Fenton reaction, initiating a circulus vitiosus, and maybe DFO at the applied concentration is not able to completely remove the excess Fe2+ and diminish the negative effects of iron release originating from the high BC dose related to increased HO-1 activity. This evidence concerns the gene HMOX1 and breast cancer.