HMOX1 and breast cancer: On the other hand, the concentration of DFO we used could be enough to eliminate the iron released during ISA/REP insult in hearts without BC treatment since, in this case, we observed lower HO-1 expression compared to BC-treated hearts; consequently, the iron load of the cardiac tissue was lower, which was reflected in improved cardiac function (Figure 1-DFO) and decreased IS (Figure 2-DFO).