Increases cell survival rate; decreases LDH release; reduces cleared ROS level, MDA content and caspase-3 activity; increases SOD and CAT activities and GSH content; increases SIRT1 gene expression; down-regulates NF-κB mRNA and protein expression; and protects against high glucose-induced oxidative damage of human neuroblastoma cells. The gene discussed is SOD1; the disease is neuroblastoma.