Other researchers have demonstrated that hyperoside can regulate vascular endothelial cells by reducing low-density lipoprotein-C level, affecting nitric oxide synthase (NOS) activity, regulating NO synthesis, improving vascular endothelial function and reducing p38 MAPK, Jun N-terminal kinase (JNK), ERK, NF-κB and TNF receptor 1 (TNFR1) levels to inhibit vascular inflammation and affect atherosclerosis [85,87]. This evidence concerns the gene MAPK8 and atherosclerosis.