Kong et al. studied the effect of hyperoside on skin tumours induced by 7, 12 dimethylbenz(a)anthracene (DMBA)/12-Otetradecanoylphorbol-13-acetate (TPA) and found that hyperoside can reduce the phosphorylation of PI3K, AKT, mammalian target of rapamycin (mTOR) and AMPK [34]. This evidence concerns the gene AKT1 and skin neoplasm.