The monomeric grifolin (1) and neogrifolin (2) are well known to possess diverse biological activities [45] such as anti-oxidative activity, anti-microbial effect, activity on human and rat vanilloid receptor 1, inhibition of tumor cell growth, promotion of melanin synthesis by B 16 melanin, inhibition of nitric oxide production in RAW 264.7 cells, the anti-cholesteremic activity level in blood and liver and plant growth inhibition. The gene discussed is TRPV1; the disease is neoplasm.