BCL2 and colonic neoplasm: Compared with normal intestinal epithelial cells, the mRNA (Messenger RNA) expression of apoptosis-related gene BCL-2 (B-cell lymphoma-2) was significantly increased (p < 0.01) and the mRNA expression of Pro-apoptotic gene BAX (BCL2-Associated X) was significantly decreased (p < 0.01) in colon cancer HCT116 and LOVO cells, indicating the high expression of Bcl-2 and low expression of BAX in colon cancer cells, which was consistent with the literature (Figure 7).