NOTCH1 and Familial prostate cancer: A study found that both procyanidin B2 3,3′′-di-O-gallate (B2G2) and grape seed procyanidins (GSP) can inhibit the self-renewal of CSCs via inhibiting Notch1 pathway activated by Jagged1 (Notch1 ligand) and restraining the transcription of Notch1 regulatory target gene HES-1, which contributes to the control of proliferating prostate cancer cells [32].