CBS and hepatocellular carcinoma: Based on the 2D-quantitative SAR analysis of quinolines and using the docking method, Mohamed et al. synthesized 29 quinoline derivatives targeting the CBS and exhibiting potent anti-proliferative activities against various human cancer cell lines including colorectal carcinoma (HCT-116), hepatocellular carcinoma (HepG-2), and breast cancer (MCF-7) [63].