CFTR and cystic fibrosis: As an example, the possible interactions of tizanidinium chloride (an α2-agonist used for the short-term treatment of muscle spasticity) with drugs from Zingiber officinale containing α2-antagonists 10-gingerol, 6-shogaol, and 8-shogaol have not been reported anywhere (not yet observed) [219] or the interaction of ivacaftor (a CFTR potentiator used to treat the management of cystic fibrosis) with tannin-containing preparations (CFTR inhibitors) used in the treatment of diarrhoea [234,235].