Among the 224 differently regulated proteins that are more abundant in male D sites are tricarboxylate transport protein (SLC25A1) [32], proteasome β-4 subunit (PSMB4) [33], and type II cytoskeletal 2 oral keratin (KRT76) [34], all with known roles in cancer (expression profiles, Supplementary Figure S22). The gene discussed is PSMB4; the disease is cancer.