A more recent publication also reported that the concomitant activation of α7 nAChRs by N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide (PHA)-543613 and σ1 receptors (σ1-Rs) by 2-(4-morpholinethyl) 1-phenylcyclohexanecarboxylate (PRE)-084 protected nigrostriatal dopaminergic neurons, the primary target of Parkinson’s disease (PD) pathology, through suppression of microglia and astrocytic inflammatory activity [54] (Table 1). This evidence concerns the gene CHRNA7 and Parkinson disease.