CHRNA7 and neuroblastoma: Moreover, a unique neuroprotective mechanism activated by α7 nAChRs was recently described in human neuroblastoma SH-SY5Y cells, in which α7 nAChRs on the cell surface bind to Aβ with high affinity and act as cargo carriers for internalization and subsequent sequestration in autophagosomes via complex formation with the autophagosome-associated protein LC3 [52] (Table 1).