TSPO and Alzheimer disease: In this study, the authors further performed the fluorescence-activated cell sorting (FACS) analysis using the radioligand-treated brain tissue of rats and AD subjects and showed that the binding signal of [125I]CLINDE, a TSPO radiotracer for SPECT, was significantly increased in astrocytes and microglia but not in vascular endothelial cells along with the progression of the pathological condition of AD.