CHRNA7 and Alzheimer disease: It has also been reported that the natural polyphenol antioxidant resveratrol upregulates α7 nAChR expression in a mouse model of AD (APdE9 mice) and human neuroblastoma SH-SY5Y cells by activating the protein deacetylase sirtuin 1 (SIRT1) and Erk1/2 signaling [57] (Table 1 and Table 2).