Indeed, the SRA (SET and RING-associated) domain of UHRF1 recognizes hemi-methylated DNA generated during DNA replication which allow UHRF1 to recruit DNMT1 in order to methylate the newly synthesized DNA strand, resulting in silencing of many TSGs in cancer [5,6,7,8,9,10,11,12,13,14]. The gene discussed is UHRF1; the disease is cancer.