In addition, LYCO given 3 days before IBD produced a significant (p < 0.05, n = 6) decrease in IL-23 levels from 16.92 ± 1.5 (no LYCO) to 12.39 ± 1.0 from 26.89 ± 2.5 to 17.49 ± 2.5 pg/mg of proteins (n = 6) on days 2, and 4 of IBD, respectively. The gene discussed is IL37; the disease is inflammatory bowel disease.