Considering that mice treated with A63 extract showed an amelioration of the OXA-stimulated hyperphosphorylation of MAPK signaling components and activation of STAT3 and STAT6 signaling (Figure 5A,B), A63 extract possibly exerts its anti-AD activity via inactivation of MAPK and JAK/STAT signaling. Here, STAT6 is linked to Alzheimer disease.