IGHE and skin disorder: The green soybean extract, irradiated with visible light, reduced dermatitis symptoms in a murine model, but failed to decrease IL-2 secretion and IgE expression, while non-irradiated soybean extract failed to prevent dermatitis-like skin inflammation, indicating that soybean may possess an anti-dermatitis effect due to its content of isoflavones, but only after the conversion or enrichment of isoflavones through chemical or microbial processing [37].