Overall, treatment with A63 extract reversed OXA-induced atopic symptoms in mice, including rash, epidermal thickening, and hyperplasia, restored the protein levels of filaggrin and loricrin, and inhibited the expression of AD markers via MAPK and STAT3/6 signaling inactivation, thus improving skin conditions to control levels. The gene discussed is STAT3; the disease is Alzheimer disease.