COX4I1 and hereditary disease: Figure 6 shows that, as was the case for the genetic diseases, TBI also causes a reduction in the levels of COX IV1 even three weeks after infliction of the damage in brains. In this case, and as shown before [30,31], the administration of Nano-PSO increases COX IV1 levels both in the control and in the pre- and post-TBI mice.