The excellent and thorough review of Kelemen et al. of 5-HT6R as a target in AD with all the data regarding computational modeling tools in the field of 5-HT6R drug design, including ligand-based information, pharmacophore models, quantitative structure-activity relationship methods, crystal structure templates, homology models, along with the main goals and challenges in discovery new 5-HT6 antagonists, is very important and useful guide for the design of new 5-HT6R antagonists [42]. This evidence concerns the gene HTR6 and Alzheimer disease.