Performing a retrospective study on PCa patients with biochemical recurrence, Su et al. found that SPECT/CT imaging with [99mTc]Tc-HYNIC-ALUG can identify more metastatic lesions and offers a higher detection rate than other imaging techniques such as MRI and bone scanning, even when the patient PSA levels are low [148]. This evidence concerns the gene KLK3 and posterior cortical atrophy.