This observation was supported by small-animal imaging in SCID mice bearing LNCaP tumor xenografts showing high uptake of the tracer at 2 h p.i. Conversely, no uptake was observed in tumors grown from PSMA-negative PC3 cells, and a marked reduction in LNCaP tumor accumulation was detected in blocking studies, indicating that the uptake is a receptor-mediated process. Here, FOLH1 is linked to neoplasm.