3.2. Uric Acid-Accelerated Atherosclerosis Progress in ApoE−/− Mice with Elevated Serum Cholesterol Level, Decreased Hepatic Bile Acid Level. The Effects at Least in Part from Activation of FXR and Down-Regulation of CYP7A1 in the Liver. Here, CYP7A1 is linked to atherosclerosis.