FMO5 and wet macular degeneration: Moreover, in light of a central role for endothelial NADPH oxidase activation in VEGF-mediated signaling that evoke retinal neoangiogenesis, the spirulina chromophore phycocyanobilin, a biliverdin derivative that can mimic the NADPH oxidase-inhibitory effects of its chemical relative bilirubin, may have potential for prevention and control of wet AMD [121,122,123,124,125,126].