Carotenoids through various signaling pathways and mechanism such as activation of AMPK, expression of autophagy biochemical markers (p62/LC3-II), activation of Keap1-Nrf2/EpRE/ARE signaling pathway, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), increased level of reactive oxygen species, cleaved poly (ADP-ribose) polymerase (c-PARP), c-caspase-3, -7, decreased level of Bcl-xL, cycle arrest at the G0/G1 phase and decreasing STAT3 expression results in apoptosis induction and inhibition of cancer cell proliferation. This evidence concerns the gene KEAP1 and cancer.