Here, changes in Nptx1 and Prrt2, which affect glutamatergic transmission and the significant enrichment of glutamatergic and GABAergic synapses KEGG pathways, support the hypothesis that an alteration in the cortical glutamate levels in the GABAergic pathway may contribute to stress-induced mood disorders and depression [64,65]. Here, NPTX1 is linked to major depressive disorder.