In this contest, Franzago et al. showed an increased risk of GDM in women carriers of the TT genotype of the TCF7L2 rs7903146 [177,178], as well as an association between nutrigenetic variants in PPARG2, APOA5, MC4R, LDLR, and FTO genes and lipid parameters at the third trimester of pregnancy. This evidence concerns the gene MC4R and gestational diabetes.