TNF and polycystic ovary syndrome: For instance, patients affected by polycystic ovary syndrome (PCOS) show increased inflammatory markers, together with increased levels of C-reactive protein (CRP), IL-18, TNF-α, IL-6, white blood cell count (WBC), monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein-1α (MIP-1α) [38].