L. plantarum-12 oral administration attenuated colon cancer of the AOM/DSS-treated mice via inhibiting NF-κB and p38 MAPK signaling pathways, including down-regulating p65, p-p65, p-p38 and up-regulating IκB-α protein expression. The gene discussed is NFKB1; the disease is malignant colon neoplasm.