Compared with NC group, IκB-α level was decreased in the AOM/DSS group, while L. plantarum-12 oral administration could improve the IκB-α level in the HLP12 group (p < 0.05), as shown in Figure 5C. As such, L. plantarum-12 oral administration was able to alleviate AOM/DSS-induced colon cancer via inhibiting the expression of p65, p-p65, and p-p38 phosphorylation in colon. This evidence concerns the gene NFKBIA and malignant colon neoplasm.