All these findings suggest that Nuci improves whole body glucose and lipid metabolism and ameliorates hepatic steatosis through directly activating AMPK signaling pathway, which subsequently leads to the inhibition of lipogenesis, promotion of lipolysis and fatty acid oxidation, as well as upregulation of the expressions of FGF21 and ZAG in liver/hepatocytes and eWAT/adipocytes. Here, FGF21 is linked to fatty liver disease.