Citrus PMFs, such as nobiletin and tangeretin, exerted beneficial effects on cognitive function in numerous experimental models—e.g., AD, Parkinson’s disease, and cardiovascular dementia [36,37,38,39,40]—by modulating pathological features such as Aβ/tau pathology, oxidative stress, and neuroinflammation and improving synaptic plasticity in several experimental models [41,42,43,44]. This evidence concerns the gene MAPT and Alzheimer disease.