In our study, differentially expressed lncRNAs were used to predict their target genes, and we found that EVs significantly up-regulated the expression of the Slc9a8 (solute carrier family 9 member A8), Tnfaip8 (TNF-α-induced protein 8), and Crept (Cell cycle-related and expression elevated protein in the tumor) and down-regulated the expression of the Sema5a (Semaphorin 5A) and Morrbid (myeloid RNA regulator of BCL2L11 induced cell death) genes in DSS-treated mice. The gene discussed is TNFAIP8; the disease is neoplasm.