Meanwhile, 13 KEGG pathways were significantly annoted (Figure 3B), including the ErbB signaling pathway, circadian entrainment, endometrial cancer, prostate cancer, pathways in cancer, fat digestion and absorption, bacterial invasion of epithelial cells, transcriptional misregulation in cancer, mucin type O-Glycan biosynthesis, signaling pathways regulating the pluripotency of stem cells, adherens junction, vitamin digestion and absorption, and morphine addiction. The gene discussed is EGFR; the disease is Familial prostate cancer.