On the other hand, some other authors have suggested that the hypoglycemic effect of millet is a direct effect mediated by its active proteins, especially prolamin, which can reduce the incidence of T2DM by attenuating hyperlipidemia and improving IR through inhibiting pancreatic lipase, suppressing lipoxygenase, and reducing TGs hepatic accumulation [51,53]. Here, PNLIP is linked to type 2 diabetes mellitus.