To explore whether IFABP−/− and LFABP−/− mice displayed alterations in the gut microbiota, we collected fecal samples from WT, IFABP−/−, and LFABP−/− mice (n = 6 per group) at both week 0 (8 weeks of age, prior to the HFD feeding period) and at week 11 of HF feeding, to profile gut microbiota composition via 16S rRNA gene V4 sequencing. This evidence concerns the gene FABP1 and hydrops fetalis.