The definition of CKD mineral and bone disorders (CKD-MBD) syndrome was first coined in 2006 by experts, in the context of Kidney Disease Improving Global Outcomes (KDIGO) guidelines, describing a complex systemic condition that includes one or more of the following: (a) laboratory abnormalities of bone and mineral metabolism involving calcium, phosphorus, parathyroid hormone (PTH), or vitamin D; (b) abnormalities in bone turnover, mineralization, volume, or strength; (c) extra-skeletal calcifications, such as vascular or other soft tissue [3]. The gene discussed is PTH; the disease is kidney disorder.