Furthermore, administration of cold-pressed perilla oil was observed to significantly reduce the expression of the peroxisome proliferator-activated receptor (PPAR)γ and fatty acid synthase (FAS) activities in incidences of high-fat diet-induced obesity in mice, leading to an inhibition of hepatic steatosis [69]. The gene discussed is PPARG; the disease is obesity due to melanocortin 4 receptor deficiency.