CASP8 and breast cancer: For example, the selenylated polysaccharides from Artemisia sphaerta induced HepG-2 cell apoptosis by activating the death receptor pathway via upregulating apoptotic protein caspase-8 [29], while the Se-enriched Ganoderma lucidum could induce the apoptosis of human breast cancer MCF-7 cells via MMP disruption and activating the mitochondrial apoptosis pathway with upregulated apoptotic protein caspases-3/-8/-9 [5].