NGLY1 and Intellectual disability: The bi-allelic mutations of NGLY1 could lead to the rare autosomal recessive congenital disorder of deglycosylation (CDD, OMIM#615273) which was characterized with global developmental delay/intellectual disability (100%), muscular hypotonia (84%), peripheral neuropathy (83%), movement disorder (81%), microcephaly (72%) and poor or absent tear production (76%) [4,20].