A significantly lower ORR after AZA was associated with ECOG ≥2 (OR 2.98, 95% CI 1.622–5.738), secondary AML (OR 1.988, 95% CI 1.283–3.090) and estimated glomerular filtrate rate < 45 mL/min/1.73 m2 (OR 3.446, 95% CI 1.134–14.006), and NPM1 wild type (OR 2.204, 95% CI 1.020–4.737); while bone marrow blast count ≥ 50% was the only factor adversely influencing ORR to DEC (OR 2.317, 95% CI 1.001–5.444) (Supplementary Materials, Figure S1). The gene discussed is NPM1; the disease is acute myeloid leukemia.