ABCG2 and cancer: Similarly, ABCG2-mediated resistance to the ABCG2 drug substrates mitoxantrone, topotecan and SN-38 [54,55] was not reversed by ensartinib in ABCG2-overexpressing S1-MI-80 or H460-MX20 cancer cell lines, or in the ABCG2-transfected R482-HEK293 cell line (Table 3).