ABCG2 and cancer: In contrast, ensartinib was equally cytotoxic to the ABCG2-overexpressing human S1-MI-80 colon cancer cells and the ABCG2-overexpressing H460-MX20 human non-small-cell lung cancer (NSCLC) cells as to the parental S1 and NCI-H460 cancer cells (Table 1).