EFNB3 and posterior cortical atrophy: In summary, our findings indicate that overexpression of prostate stromal EFNB ligands (EFNB1 and EFNB3) plays a role in PCa tumorigenesis by modulating the TME through alterations in the fibroblast secretome, with multiple effects on neovascularization, collagen deposition, cancer cell proliferation, and migration.