Higher pre-treatment CRP (HR = 2.22; 95% CI: 1.12–4.42; p = 0.023), tonsil location (HR = 3.20; 95% CI: 1.19–8.60; p = 0.021), and alcohol abuse (HR = 3.86; 95% CI: 1.00–14.86; p = 0.050) were independent adverse prognostic factors, while higher BMI (HR = 0.32; 95% CI: 0.14–0.72; p = 0.006) and positive HPV status (HR = 0.36; 95% CI: 0.16–0.80; p = 0.012) were good prognostic factors for OS (Table S5). The gene discussed is CRP; the disease is alcohol abuse.