In HPV- patients, higher pre-treatment CRP (HR = 2.90; 95% CI: 1.08–7.76; p = 0.034), higher lymph node status (HR = −4.26; 95% CI: 1.59–11.43; p = 0.004), higher NRS 2002 (HR = 5.89; 95% CI: 1.79–19.37; p = 0.003), and alcohol abuse (HR = 8.01; 95% CI: 1.41–45.39; p = 0.0019) were significant independent adverse prognostic factors for DFS, while higher hemoglobin concentration (HR = 0.34; 95% CI: 0.13–0.90; p = 0.029) was a good predictor for DFS. Here, CRP is linked to alcohol abuse.