Multiple staging procedures, including digital rectal examination (DRE), prostate-specific antigen (PSA) serum levels, transrectal ultrasonography (TRUS), positron emission tomography–computed tomography (PET/CT), and multiparametric magnetic resonance imaging (mpMRI), are aimed at evaluating PCa expanse preoperatively. This evidence concerns the gene KLK3 and posterior cortical atrophy.