We performed a rank test using the Kruskal–Wallis method, which showed significant differences in the average numbers of connections within EGF (p-value = 9.06 × 10−9), FGF (p-value = 0.0001923), HEDGEHOG (p-value = 1.435 × 10−8), NF-B (p-value = 4.946 × 10−8), NOTCH (p-value = 1.135 × 10−8), TGF-β (p-value = 0.01458), and WNT (p-value = 2.923 × 10−10) pathways among the six cancer types. Here, EGF is linked to cancer.