On the other hand, DNA-PKcs overexpression regulates mTORC2-AKT activation and HIF-2 expression in renal cell carcinoma (RCC) cells [69] and has been involved in cell proliferation and oncogenic transformation by the stabilization of c-Myc oncoprotein via the AKT/GSK3 pathway in cancer cell lines [70]. This evidence concerns the gene AKT1 and hereditary clear cell renal cell carcinoma.