Two examples of such distribution differences of two upregulated genes between H and L cancer classes are PRICKLE1, a WNT signaling component that contains six raw connections that was sampled more frequently in L tumors (49%) compared to H classes (2.5%) and PSMC6, a proteasomal subunit with 59 raw connections (hub) that was sampled more frequently in H tumors (40%) compared to class L (3%). This evidence concerns the gene PRICKLE1 and cancer.