While HCC, one of the most recurrent primary malignant liver tumors, was classified in proliferative and non-proliferative tumors [161,162], considering its molecular and histopathological features with subclassifications involving grade of differentiation or oncogenic pathways, such as RAS/MAPK and PI3K/AKT in the proliferative type and JAK/STAT and Wnt/b catenin in the non-proliferative one [157]. The gene discussed is AKT1; the disease is hepatocellular carcinoma.