ACh and cholinergic-related components were also demonstrated in human lung cancers, inducing adhesion migration and invasion [34] in a sort of autocrine manner via a cholinergic autocrine loop [65], while the M3 autocrine loop was highly expressed in SCLC; this expression was detected after the examination of 24 SCLC samples in which 17 were positive, and where choline acetyltransferase (ChAT) was also expressed [80]. Here, CHAT is linked to small cell lung carcinoma.