CHRM3 and colonic neoplasm: Bethanechol treatment increased the expression of CHRM3, EGFR, and post-EGFR signaling molecules Myc and cyclin D1 in colon cancer; it also increased the thickness of normal colonic mucosa and the expression of selected MMP genes, such as MMP7, MMP10, and MMP13, indicating that mAChRs play a key role in colon neoplasia and pointing to post-receptor signaling molecules as potential therapeutic targets [152].