EGFR and glioblastoma: On the hand, authors studied these interactions in human glioblastoma cell lines (U251MG and U87MG) and reported that, under arecaidine propargyl ester (APE), a muscarinic agonist, the M2 receptors were activated, which induced upregulation of miRNA 34a-5p expression, and that would eventually downregulate the expression of both Notch-1 and EGFR [203].