They studied such components as an extracellular matrix with collagen composition and arrangement, fibronectin and hyaluronan deposition, cancer-associated fibroblasts (α-SMA staining and collagen density with the use of the so-called activated stroma ratio [114,115]), and cancer–stroma interactions (integrins α2, α5, β1, metalloproteinases—MMP14 and caveolin-1). Here, ACTA1 is linked to cancer.