Tumor cells in advanced cervical cancer [54], malignant pleural mesothelioma [55], ovarian cancer [56] and renal cell carcinoma [57] secrete CXCL12, which recruits both TAMs and T-regulatory cells (Tregs) via binding to CXCR4 expressed at high levels on their surface. Here, CXCL12 is linked to neoplasm.