Therefore, we decided to investigate and compare the impact of LDH-A depletion (both LDH-A shRNA knockdown (KD) and treatment with a specific LDH-A/B inhibitor (GNE-R-140)) on the expression of LDH-B in different murine glioma cell lines and corresponding i.c. tumors. The gene discussed is LDHA; the disease is central nervous system cancer.