LDHA and malignant glioma: It is also known that MiR-200b is a regulator of tumor progression and metabolism targeting LDH-A in human malignant gliomas [29], and that upregulation of KLHDC8A (Kelch domain-containing 8A) is induced by lactate and contributes to the proliferation, migration, and apoptosis of human glioma cells [20].