In conclusion, our findings support the role of MEOX2 as an important transcription factor in glioblastoma stem cells, where its depletion profoundly represses key genes of the glycolytic pathway involved in the Warburg effect along with several other genes engaged in the high ability of GSCs to respond to hypoxic and other types of stress, making them resistant to therapies and to the microenvironment where they reside. This evidence concerns the gene MEOX2 and glioblastoma.