Finally, ALDOC encodes for the C isozyme in the family of aldolases, which catalyzes the conversion of fructose 1,6-bisphosphatase to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate (DHAP) during glycolysis, and is highly enriched in the brain as compared to any other healthy tissue, and in glioblastoma tissues [39], despite its mRNA levels being inversely correlated with glioma tumor grades (being higher in grade 2 and 3 gliomas, compared to grade 4 tumors) in one study [48]. This evidence concerns the gene FBP1 and glioma.