LDHA and central nervous system cancer: Furthermore, a bioinformatics analysis of mRNA expression data showed that: (i) GL261 LDH-A KD cells may have a less glycolytic dependency and an improved ability to metabolize substrates through the TCA cycle; and (ii) that GL261 LDH-A KD cells can upregulate oxidative phosphorylation pathways, while the other glioma cell lines do not have this capacity.