LDHA and central nervous system cancer: We found that LDH-A KD resulted in a reduction in glycolysis (GlycoPER) of all three cell lines, whereas a significant increase in the basal respiratory rate (mitoOCR) was only observed in GL261 cells; this suggests that GL261 glioma cells are more energetically limited (with the lowest ATP production) compared to CT2A and ALTS1C1 cells.