To investigate the IL-6 signaling pathway in human IBC, the distribution of IL-6, the tyrosine phosphorylated and activated form of the latent transcription factor STAT3 (pSTAT3) and HER2 protein was evaluated qualitatively in 15 formalin-fixed and paraffin-embedded core biopsy specimens of all clinical subtypes (luminal, HER2 amplified, and TNBC) from treatment-naïve IBC patients (Table S1). This evidence concerns the gene IL6 and inflammatory breast carcinoma.