To do this, the authors designed a CD4 TGF-β Trap (4T-Trap), which consisted of the TGF-β-neutralizing TGFBR2 extracellular domain attached to a non-immunosuppressive CD 4 antibody; 4T-Trap inhibited the TGF-β signaling cascade in TH cells, leading to remodeling of vasculature and cancer cell death [310]. This evidence concerns the gene TGFB1 and cancer.