As expected, a decrease in the expression of targets of NF-κB as matrix metalloproteinases (MMPs), cyclooxygenase 2 (COX2), and nitric oxide synthase (NOS)3 were revealed by RNAseq of blood outgrowth endothelial cells from VHL disease patients, as a model to assess the systemic effects in other organs predisposed to develop malignant tumors [46]. Here, PTGS2 is linked to cancer.