It was also obvious that CAFs derived from the AT (αSMA-low, SOX2-high, p16+) or BA (αSMA- and EGFR-high and low SOX2/TP63 ratio) mRNA subtypes could support the growth of both types of tumour cells (primary-tumour ones as well as metastatic-derived ones), while CL and ME CAFs were more specific. This evidence concerns the gene SOX2 and neoplasm.