CD40LG and Miyoshi myopathy: Among patients with newly diagnosed MM patients, some studies have found that high-risk cytogenetics at diagnosis (defined as del17p, t(4;14), add1q21, t(14;16), t(14;20), or nonhyperdiploid karyotype) was associated with a higher incidence of polyclonal immunoglobulin suppression, notably lower IgM levels [12,15].