In multivariate analysis, including tumor type (melanoma vs. other), ECOG (0 vs. other), presence of grade ≥ 3 irAEs, and peripheral blood C-reactive protein (CRP) level (under or ≥10 mg/L), the association between improved PFS and grade ≥ 3 irAEs was retained (Table 3, Figure 1A). The gene discussed is CRP; the disease is melanoma.