ASCL1 and small cell lung carcinoma: Since SCLC cell lines are classified into four biologically distinct subtypes (ASCL1, NEUROD1, YAP1, and POU2F3) [39], we selected DMS53, H146, H128, H372, DMS153, H69, H209 (ASCL1), H446 (NEUROD1), DMS114, H196 (YAP1), H1048, and H526 (POU2F3) in our study, representing each subtype.